Boston: A groundbreaking study published in Nature Neuroscience reveals how exercise may protect the brain from Alzheimer’s disease at a cellular level. Using single-nuclei RNA sequencing (snRNA-seq), researchers from Massachusetts General Hospital examined brain cells in mouse models of Alzheimer’s and confirmed their findings in human tissue.
They found that regular physical activity altered the function of immune cells (microglia) and neurovascular-associated astrocytes (NVAs) in the hippocampus, an area critical for memory and learning.
Exercise boosts neuroprotective gene expression and activates a metabolic gene called ATPIF1, which may promote the growth of new neurons. “This study offers molecular insight into how exercise strengthens brain resilience,” said lead author Dr. Christiane Wrann.
Experts say the findings pave the way for future Alzheimer’s treatments targeting these cells and processes. While the disease remains incurable, scientists stress that lifestyle changes like physical activity can help reduce risk and slow its progression.
